Low plasma leptin levels contribute to diabetic hyperphagia in rats
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چکیده
منابع مشابه
Plasma leptin levels in rats with pancreatitis.
Diagnosis of pancreatitis is based on the determination of serum amylase and lipase levels. However, recent identification of specific leptin receptors in the pancreas suggests that this peptide may also play some roles in the modulation of pancreatic function. The objective of the present study was to investigate the relationship between serum leptin levels and pancreatitis. Thirty male Wistar...
متن کاملHyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY.
Chronic cold exposure stimulates sympathetically driven thermogenesis in brown adipose tissue (BAT), resulting in fat mobilization, weight loss, and compensatory hyperphagia. Hypothalamic neuropeptide Y (NPY) neurons are implicated in stimulating food intake in starvation, but may also suppress sympathetic outflow to BAT. This study investigated whether the NPY neurons drive hyperphagia in rats...
متن کاملeffects of yohimbine on plasma levels of leptin in normal and streptozotocin induced diabetic rats
leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action. the reducing effect of α2-adrenoceptors inhibition on body weight and appetite and also enhancing effects on lipolysis, sympathetic activation and plasma insulin levels in animals have been reported. we studied the effect of yohimbine treatment (2 mg...
متن کاملRelation between Plasma Levels of Ghrelin and Hyperphagia in Streptozotocin-Induced Diabetes in Male Albino Rats
Background: Ghrelin, a hormone identified in the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and the peripheral or central administration of ghrelin increases food intake and body weight. Ghrelin release and gene expression are regulated by nutrient flux, such that plasma ghrelin levels increase steadily before meal onset and fall rapidly after food ing...
متن کاملComparison of plasma leptin levels in patients with normal, low and high risk myocardial perfusion scan [Persian]
Introduction: Leptin, secreted from adipose tissue may have some correlation with coronary artery disease according to some reports in literature. The mean concentration of plasma leptin in patients with normal and abnormal myocardial perfusion imaging (MPI) and relation of leptin levels, independently to abnormality in MPI after correction for body mass index (BMI) was evaluated. Methods...
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ژورنال
عنوان ژورنال: Diabetes
سال: 1999
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.48.6.1275